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J. Barry McKernan, MD, PhD—A Profile
Dr. Barry McKernan, who performed the first laparoscopic cholecystectomy in the United States, has followed a surgical trail that truly represents the spirit of the American surgeon. He completed his undergraduate studies at a time when American medicine, American surgery, and clinically related research were beginning their Golden Age. The interval was the mid 1960s. Medical students and gradu...
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The overarching goal of my research is to understand the biological role of C-reactive protein (CRP) in maintenance of health and propagation of disease. Diseases of interest include: systemic lupus erythematosus, multiple sclerosis, rheumatoid arthritis, septic arthritis, diabetes, Alzheimer's, cardiovascular disease, and microbial infection. We use a multi-faceted approach that entails studie...
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The AsF6 anion, in the crystalline polymer electrolyte PEO6:LiAsF6, was replaced with the larger N(SO2CF3)2 anion. This produced an increase in the room temperature ionic conductivity of 1.5 orders of magnitude. It is believed that the enhancement is the result of the disruption of the electrostatic field around the lithium ions. The presence of the large and asymmetrical N(SO2CF3)2 ion creates...
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T wo decades ago, David Mangelsdorf did not expect his basic research findings to help launch an entire field of biology with farreaching implications for a raft of human diseases, including cancer, metabolic disorders, and parasitic infections. Mangelsdorf, a Howard Hughes Medical Institute investigator and a professor of pharmacology at the University of Texas Southwestern Medical Center at D...
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Protein homeostasis is crucial to the health of living cells, and dysregulated protein homeostasis can trigger diseases, including cancer. Biochemical cell biologist Raymond Deshaies has devoted his distinguished career to the analysis of protein homeostasis and the development of therapeutic approaches to counter diseases that result when homeostasis goes awry. Deshaies has served as a profess...
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ژورنال
عنوان ژورنال: BioTechniques
سال: 2008
ISSN: 0736-6205,1940-9818
DOI: 10.2144/000112934